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5- (3-Azidopropyl) cytidine

5- (3-Azidopropyl) cytidine is a cytidine nucleoside analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities[1]. 5- (3-Azidopropyl) cytidine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Product Specifications

UNSPSC

12352005

Target

Nucleoside Antimetabolite/Analog

Type

Oligonucleotides

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/5-3-azidopropyl-cytidine.html

Solubility

10 mM in DMSO

Smiles

O[C@H]1[C@@H](O)[C@H](N2C=C(CCCN=[N+]=[N-])C(N)=NC2=O)O[C@@H]1CO

Molecular Formula

C12H18N6O5

Molecular Weight

326.31

References & Citations

[1]Gowher H, et al. Mechanism of inhibition of DNA methyltransferases by cytidine analogs in cancer therapy. Cancer Biol Ther. 2004 Nov;3 (11) :1062-8.

Shipping Conditions

Room temperature

Scientific Category

Oligonucleotides

Clinical Information

No Development Reported

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