TLR7 agonist 9

TLR7 agonist 9 (compound 10) is an aonist of TLR7. TLR7 agonist 9 can be used for research of cancer and infectious disease[1]. TLR7 agonist 9 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Product Specifications

CAS Number

[2389988-38-7]

UNSPSC

12352005

Target

Nucleoside Antimetabolite/Analog; Toll-like Receptor (TLR)

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Immunology/Inflammation

Applications

COVID-19-anti-virus

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/tlr7-agonist-9.html

Solubility

10 mM in DMSO

Smiles

OC[C@@H]1[C@H](O)[C@@H](O)[C@H](N(C(N2CC#CCO)=O)C3=C2C(NC(N)=N3)=O)O1

Molecular Formula

C14H17N5O7

Molecular Weight

367.31

References & Citations

[1]Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18 (23) :3373-88.|[2]Webber Stephen E, et al. TLR7 agonists for treatment of cancer and infectious disease. World Intellectual Property Organization, WO2019226977 A1. 2019-11-28.