6-O-Methylinosine

6-O-Methylinosine is a hypoxanthine analogue. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly (ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia[1][2].

Product Specifications

CAS Number

[5746-29-2]

UNSPSC

12352005

Hazard Statement

H302-H315-H319

Target

Nucleoside Antimetabolite/Analog; Xanthine Oxidase

Type

Oligonucleotides

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/6-o-methylinosine.html

Solubility

10 mM in DMSO

Smiles

O[C@H]1[C@@H](O)[C@H](N(C=N2)C3=C2C(OC)=NC=N3)O[C@@H]1CO

Molecular Formula

C11H14N4O5

Molecular Weight

282.25

Precautions

P264-P270-P280-P302+P352-P330-P362+P364-P501

References & Citations

[1]Virág L, Szabó C. Purines inhibit poly (ADP-ribose) polymerase activation and modulate oxidant-induced cell death. FASEB J. 2001 Jan;15 (1) :99-107.|[2]Saugstad OD. Hypoxanthine as an indicator of hypoxia: its role in health and disease through free radical production. Pediatr Res. 1988 Feb;23 (2) :143-50.