2-Chloro-9- (2-deoxy-2-fluoro-β-D-arabinofuranosyl) -6-methoxy-9H-purine
2-Chloro-9- (2-deoxy-2-fluoro-β-D-arabinofuranosyl) -6-methoxy-9H-purine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Product Specifications
CAS Number
[758705-70-3]
UNSPSC
12352005
Hazard Statement
H302-H315-H320-H335
Target
Nucleoside Antimetabolite/Analog
Type
Oligonucleotides
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/2-chloro-9-2-deoxy-2-fluoro-β-d-arabinofuranosyl-6-methoxy-9h-purine.html
Solubility
10 mM in DMSO
Smiles
OC[C@@H]1[C@@H](O)[C@H](F)[C@H](N2C=NC3=C2N=C(Cl)N=C3OC)O1
Molecular Formula
C11H12ClFN4O4
Molecular Weight
318.69
Precautions
P264-P270-P330
References & Citations
[1]Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18 (23) :3373-88.
Shipping Conditions
Room temperature
Scientific Category
Oligonucleotides
Clinical Information
No Development Reported
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