Antimalarial agent 19
Antimalarial agent 19 (compound 6e) is an antimalarial active agent. Antimalarial agent 19 has antimalarial activity for the blood stage of P. falciparum K1 and P. berghei with EC50 values of 0.3 µM, 15.3 µM, respectively. Antimalarial agent 19 has good aqueous solubility, intestinal permeability and microsomal stability compared to gamhepathiopine[1].
Product Specifications
CAS Number
[2897630-89-4]
UNSPSC
12352005
Target
Parasite
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/antimalarial-agent-19.html
Solubility
10 mM in DMSO
Smiles
CC1=CC=C(C=C1)C2=CC3=C(C(NCCCN(C)C)=NC(NC(C)(C)C)=N3)S2.Cl.Cl
Molecular Formula
C22H33Cl2N5S
Molecular Weight
470.50
References & Citations
[1]Lagardère P, et al. New antiplasmodial 4-amino-thieno[3,2-d]pyrimidines with improved intestinal permeability and microsomal stability. Eur J Med Chem. 2023 Jan 13;249:115115.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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