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Antimalarial agent 19

Antimalarial agent 19 (compound 6e) is an antimalarial active agent. Antimalarial agent 19 has antimalarial activity for the blood stage of P. falciparum K1 and P. berghei with EC50 values of 0.3 µM, 15.3 µM, respectively. Antimalarial agent 19 has good aqueous solubility, intestinal permeability and microsomal stability compared to gamhepathiopine[1].

Product Specifications

CAS Number

[2897630-89-4]

UNSPSC

12352005

Target

Parasite

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/antimalarial-agent-19.html

Solubility

10 mM in DMSO

Smiles

CC1=CC=C(C=C1)C2=CC3=C(C(NCCCN(C)C)=NC(NC(C)(C)C)=N3)S2.Cl.Cl

Molecular Formula

C22H33Cl2N5S

Molecular Weight

470.50

References & Citations

[1]Lagardère P, et al. New antiplasmodial 4-amino-thieno[3,2-d]pyrimidines with improved intestinal permeability and microsomal stability. Eur J Med Chem. 2023 Jan 13;249:115115.

Shipping Conditions

Room temperature

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-152614/Antimalarial-agent-19-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-152614/

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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