XL413 (hydrochloride)

XL413 (BMS-863233) hydrochloride is an orally active and selective CDC7 inhibitor (IC50=3.4 nM) . XL413 hydrochloride has favorable pharmacokinetic profiles and significantly inhibits tumor growth in rodent models. XL413 hydrochloride can be used in cancer research[1].

Product Specifications

CAS Number

[1169562-71-3]

Product Name Alternative

BMS-863233 (hydrochloride)

UNSPSC

12352005

Hazard Statement

H301

Target

CDK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/xl413-hydrochloride-1.html

Solubility

10 mM in DMSO

Smiles

ClC1=CC=C2C(C(N=C([C@@H]3CCCN3)NC4=O)=C4O2)=C1.Cl.[x]

Molecular Formula

C14H12ClN3O2.xHCl

Precautions

P264-P270-P330-P405-P501

References & Citations

[1]Koltun ES, et al. Discovery of XL413, a potent and selective CDC7 inhibitor. Bioorg Med Chem Lett. 2012 Jun 1;22 (11) :3727-31. doi: 10.1016/j.bmcl.2012.04.024. Epub 2012 Apr 16. Erratum in: Bioorg Med Chem Lett. 2012 Aug 1;22 (15) :5157.