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5-[3-[ (2,2,2-Trifluoroacetyl) amino]-1-propyn-1-yl]uridine

5-[3-[ (2,2,2-Trifluoroacetyl) amino]-1-propyn-1-yl]uridine is a thymidine analogue. Analogs of this series have insertional activity towards replicated DNA. They can be used to label cells and track DNA synthesis[1]. 5-[3-[ (2,2,2-Trifluoroacetyl) amino]-1-propyn-1-yl]uridine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Product Specifications

CAS Number

120609-05-4

UNSPSC

12352005

Target

Nucleoside Antimetabolite/Analog

Type

Oligonucleotides

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/5-3-2-2-2-trifluoroacetyl-amino-1-propyn-1-yl-uridine.html

Solubility

10 mM in DMSO

Smiles

O[C@@H]1[C@H](O)[C@H](N2C(NC(C(C#CCNC(C(F)(F)F)=O)=C2)=O)=O)O[C@@H]1CO

Molecular Formula

C14H14F3N3O7

Molecular Weight

393.27

References & Citations

[1]Cavanagh BL, et al. Thymidine analogues for tracking DNA synthesis. Molecules. 2011 Sep 15;16 (9) :7980-93.

Shipping Conditions

Room temperature

Scientific Category

Oligonucleotides

Clinical Information

No Development Reported

Frequently Asked Questions

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