5-[3-[ (2,2,2-Trifluoroacetyl) amino]-1-propyn-1-yl]uridine
5-[3-[ (2,2,2-Trifluoroacetyl) amino]-1-propyn-1-yl]uridine is a thymidine analogue. Analogs of this series have insertional activity towards replicated DNA. They can be used to label cells and track DNA synthesis[1]. 5-[3-[ (2,2,2-Trifluoroacetyl) amino]-1-propyn-1-yl]uridine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Product Specifications
CAS Number
120609-05-4
UNSPSC
12352005
Target
Nucleoside Antimetabolite/Analog
Type
Oligonucleotides
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/5-3-2-2-2-trifluoroacetyl-amino-1-propyn-1-yl-uridine.html
Solubility
10 mM in DMSO
Smiles
O[C@@H]1[C@H](O)[C@H](N2C(NC(C(C#CCNC(C(F)(F)F)=O)=C2)=O)=O)O[C@@H]1CO
Molecular Formula
C14H14F3N3O7
Molecular Weight
393.27
References & Citations
[1]Cavanagh BL, et al. Thymidine analogues for tracking DNA synthesis. Molecules. 2011 Sep 15;16 (9) :7980-93.
Shipping Conditions
Room temperature
Scientific Category
Oligonucleotides
Clinical Information
No Development Reported
Frequently Asked Questions
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