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α-Synuclein inhibitor 8

α-Synuclein inhibitor 8 is an active inhibitor of α-Synuclein with an IC50 value of 2.5 µM. α-Synuclein inhibitor 8 has highly inhibition on the aggregation and disaggregation of α-Synuclein fibers. α-Synuclein inhibitor 8 reduces the formation of inclusions in neurons that can repairs damage neurons and improves Parkinson’s disease (PD) -like symptoms. α-Synuclein inhibitor 8 has high antioxidant activity and low cytotoxicity[1].

Product Specifications

CAS Number

2883627-64-1

UNSPSC

12352005

Target

α-synuclein

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/α-synuclein-inhibitor-8.html

Solubility

10 mM in DMSO

Smiles

OC1=CC=C(O)C=C1/C=C/C(NC2=CC=C(NC(/C=C/C3=CC(O)=CC=C3O)=O)C=C2)=O

Molecular Formula

C24H20N2O6

Molecular Weight

432.43

References & Citations

[1]Lü MH, et al. Hybrids of polyphenolic/quinone acids, the potential preventive and therapeutic drugs for PD: Disaggregate α-Syn fibrils, inhibit inclusions, and repair damaged neurons in mice. Eur J Med Chem. 2023 Jan 18;249:115122.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

α-synuclein Aggregation

Frequently Asked Questions

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