ATV041

ATV041 is an orally active Ibuprofen (HY-78131) and nucleotide analogue. ATV041 improves oral pharmacokinetic (PK) profile and tissue distribution with anti-mouse hepatitis virus (MHV) activity. ATV041 reduces viral load, tissue damage and virus-induced inflammation in a dose-dependent manner[1].

Product Specifications

CAS Number

[2935937-67-8]

UNSPSC

12352005

Target

HSV

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/atv041.html

Solubility

10 mM in DMSO

Smiles

O[C@H]1[C@@H](O)[C@](C#N)(C2=CC=C3C(N)=NC=NN32)O[C@@H]1COC(C(C)C(C=C4)=CC=C4CC(C)C)=O

Molecular Formula

C25H29N5O5

Molecular Weight

479.53

References & Citations

[1]Zhou Q, et al. Nonsteroidal anti-inflammatory drugs (NSAIDs) and nucleotide analog GS-441524 conjugates with potent in vivo efficacy against coronaviruses. Eur J Med Chem. 2023 Jan 10;249:115113.