5- (Aminomethyl) uridine

5- (Aminomethyl) uridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

Product Specifications

CAS Number

[190448-73-8]

UNSPSC

12352005

Target

Nucleoside Antimetabolite/Analog

Type

Oligonucleotides

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/5-aminomethyl-uridine.html

Purity

98.74

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(C(CN)=CN1[C@H]2[C@H](O)[C@H](O)[C@@H](CO)O2)NC1=O

Molecular Formula

C10H15N3O6

Molecular Weight

273.24

References & Citations

[1]Cavanagh BL, et al. Thymidine analogues for tracking DNA synthesis. Molecules. 2011 Sep 15;16 (9) :7980-93.|[2]Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18 (23) :3373-88.