Topoisomerase IIα-IN-7
Product Specifications
UNSPSC Description
Topoisomerase IIα-IN-7 is an DNA topoisomerase IIα inhibitor with an IC50 value of 7.7 µM. Topoisomerase IIα-IN-7 has broad-spectrum cytotoxicity to leukemia, lung, colon, melanoma, ovarian, kidney, prostate and breast cancer cells. Topoisomerase IIα-IN-7 has metabolic stability[1].
Target Antigen
Topoisomerase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/topoisomerase-iiα-in-7.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=C(OCC2=CC(C(NC3CCCNC3)=O)=CC=C2)C=CC=C1)C4=C(Cl)C(Cl)=C(C)N4.Cl
Molecular Weight
537.87
References & Citations
[1]Skok Ž, et al. ATP-competitive inhibitors of human DNA topoisomerase IIα with improved antiproliferative activity based on N-phenylpyrrolamide scaffold. Eur J Med Chem. 2023 Jan 18;249:115116.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-152479/Topoisomerase-IIα-IN-7-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-152479/
Clinical Information
No Development Reported
Curated Selection
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