Topoisomerase IIα-IN-6
Product Specifications
UNSPSC Description
Topoisomerase IIα-IN-6 (Compound 47d) is an inhibitor of DNA topoisomerase IIα/β. Topoisomerase IIα-IN-6 inhibits human topoisomerase IIα and human topoisomerase IIβ with IC50 values of 0.67 µM and 0.55 µM, respectively. Topoisomerase IIα-IN-6 has stable metabolism[1].
Target Antigen
Topoisomerase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/topoisomerase-iiα-in-6.html
Solubility
10 mM in DMSO
Smiles
CC1=C(C(Cl)=C(N1)C(NC2=CC=C(C=C2OCC3=CC=C(C=C3)C(NCCN)=O)C(N)=O)=O)Cl.Cl
Molecular Weight
540.83
References & Citations
[1]Skok Ž, et al. ATP-competitive inhibitors of human DNA topoisomerase IIα with improved antiproliferative activity based on N-phenylpyrrolamide scaffold. Eur J Med Chem. 2023 Jan 18;249:115116.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-152473/Topoisomerase-IIα-IN-6-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-152473/
Clinical Information
No Development Reported
Curated Selection
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