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Topoisomerase IIα-IN-6

Selected Variant

HY-152473

Size: 1 Each

Topoisomerase IIα-IN-6 (Compound 47d) is an inhibitor of DNA topoisomerase IIα/β. Topoisomerase IIα-IN-6 inhibits human topoisomerase IIα and human topoisomerase IIβ with IC50 values of 0.67 µM and 0.55 µM, respectively. Topoisomerase IIα-IN-6 has stable metabolism[1].

Product Specifications

UNSPSC

12352005

Target

Topoisomerase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/topoisomerase-iiα-in-6.html

Solubility

10 mM in DMSO

Smiles

CC1=C(C(Cl)=C(N1)C(NC2=CC=C(C=C2OCC3=CC=C(C=C3)C(NCCN)=O)C(N)=O)=O)Cl.Cl

Molecular Formula

C23H24Cl3N5O4

Molecular Weight

540.83

References & Citations

[1]Skok Ž, et al. ATP-competitive inhibitors of human DNA topoisomerase IIα with improved antiproliferative activity based on N-phenylpyrrolamide scaffold. Eur J Med Chem. 2023 Jan 18;249:115116.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Topo II

Price

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