Eleven-Nineteen-Leukemia Protein IN-2

Eleven-Nineteen-Leukemia Protein IN-2 (compound 23) is an Eleven-Nineteen-Leukemia Protein (ENL) inhibitor with an IC50 value of 10.7 nM. Eleven-Nineteen-Leukemia Protein IN-2 can be used for the research of leukemia[1].

Product Specifications

CAS Number

[2894121-78-7]

UNSPSC

12352005

Target

Epigenetic Reader Domain

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/eleven-nineteen-leukemia-protein-in-2.html

Solubility

10 mM in DMSO

Smiles

CC1=NOC2=CC(C(NC3=CC=C4NC(CN5CCC[C@@H]5C)=NC4=C3)=O)=CC=C21

Molecular Formula

C22H23N5O2

Molecular Weight

389.45

References & Citations

[1]Guo S, et al. Design, synthesis of novel benzimidazole derivatives as ENL inhibitors suppressing leukemia cells viability via downregulating the expression of MYC. Eur J Med Chem. 2023 Feb 15;248:115093.