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Eleven-Nineteen-Leukemia Protein IN-1

Eleven-Nineteen-Leukemia Protein IN-1 is an inhibitor of ENL YEATS domain with an IC50 value of 14.5 nM. Eleven-Nineteen-Leukemia Protein IN-1 interacts with ENL protein and enhances the thermal stability of ENL protein in vitro[1].

Product Specifications

CAS Number

[2894121-68-5]

UNSPSC

12352005

Target

Epigenetic Reader Domain

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/eleven-nineteen-leukemia-protein-in-1.html

Solubility

10 mM in DMSO

Smiles

C[C@H]1CCCN1CC2=NC3=CC(NC(C4=CC5=C(N(N=C5)CCN6CCOCC6)C=C4)=O)=CC=C3N2

Molecular Formula

C27H33N7O2

Molecular Weight

487.60

References & Citations

[1]Guo S, et al. Design, synthesis of novel benzimidazole derivatives as ENL inhibitors suppressing leukemia cells viability via downregulating the expression of MYC. Eur J Med Chem. 2023 Feb 15;248:115093.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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