Eleven-Nineteen-Leukemia Protein IN-1
Product Specifications
UNSPSC Description
Eleven-Nineteen-Leukemia Protein IN-1 is an inhibitor of ENL YEATS domain with an IC50 value of 14.5 nM. Eleven-Nineteen-Leukemia Protein IN-1 interacts with ENL protein and enhances the thermal stability of ENL protein in vitro[1].
Target Antigen
Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/eleven-nineteen-leukemia-protein-in-1.html
Solubility
10 mM in DMSO
Smiles
C[C@H]1CCCN1CC2=NC3=CC(NC(C4=CC5=C(N(N=C5)CCN6CCOCC6)C=C4)=O)=CC=C3N2
Molecular Weight
487.60
References & Citations
[1]Guo S, et al. Design, synthesis of novel benzimidazole derivatives as ENL inhibitors suppressing leukemia cells viability via downregulating the expression of MYC. Eur J Med Chem. 2023 Feb 15;248:115093.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-152469/Eleven-Nineteen-Leukemia-Protein-IN-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-152469/
Clinical Information
No Development Reported
CAS Number
2894121-68-5
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