Antitumor agent-83
Antitumor agent-83 is an activator of pro-apoptotic protein BAX and has significant anti-proliferation effect on tumor cells. Antiumor agent-83 mediates cell Apoptosis by inducing the conformational activation of BAX and has inhibitory effect on A549 cell cycle. Antiumor agent-83 has good metabolic stability and CYPs spectrum in vitro[1].
Product Specifications
CAS Number
[9007-83-4]
UNSPSC
12352005
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/antitumor-agent-83.html
Solubility
10 mM in DMSO
Smiles
CN(C1CCN(CC1)C(C2=CC=C(C=C2)N3N=C(/C(C3=O)=N/NC4=CC=CC=C4)C5=CC=CC=C5)=O)C
Molecular Formula
C29H30N6O2
Molecular Weight
494.59
References & Citations
[1]Zhang Z, et al. Optimization of BAX trigger site activator BTSA1 with improved antitumor potency and in vitro ADMET properties. Eur J Med Chem. 2023 Feb 15;248:115076.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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