7,8-Dihydro-8-oxo-7-propargyl-3’-deoxy-3’-fluoro guanosine
Product Specifications
UNSPSC Description
7,8-Dihydro-8-oxo-7-propargyl-3’-deoxy-3’-fluoro guanosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. 7,8-Dihydro-8-oxo-7-propargyl-3’-deoxy-3’-fluoro guanosine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Target Antigen
Nucleoside Antimetabolite/Analog
Type
Oligonucleotides
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/7-8-dihydro-8-oxo-7-propargyl-3-deoxy-3-fluoro-guanosine.html
Solubility
10 mM in DMSO
Smiles
OC[C@@H]1[C@@H](F)[C@@H](O)[C@H](N2C(N(CC#C)C3=C2NC(N)=NC3=O)=O)O1
Molecular Weight
339.28
References & Citations
[1]Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-152364/7-8-Dihydro-8-oxo-7-propargyl-3-deoxy-3-fluoro-guanosine-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-152364/
Clinical Information
No Development Reported
CAS Number
2389988-55-8
Curated Selection
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