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N4- (n-Palmitoyl) -4’-azido-2’-deoxy-2’-fluoro-arabinocytidine

N4- (n-Palmitoyl) -4’-azido-2’-deoxy-2’-fluoro-arabinocytidine is a cytidine nucleoside analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities[1]. N4- (n-Palmitoyl) -4’-azido-2’-deoxy-2’-fluoro-arabinocytidine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Product Specifications

UNSPSC

12352005

Target

Nucleoside Antimetabolite/Analog

Type

Oligonucleotides

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/n4-n-palmitoyl-4-azido-2-deoxy-2-fluoro-arabinocytidine.html

Solubility

10 mM in DMSO

Smiles

O=C1N([C@H]2[C@@H](F)[C@H](O)[C@](CO)(N=[N+]=[N-])O2)C=CC(NC(CCCCCCCCCCCCCCC)=O)=N1

Molecular Formula

C25H41FN6O5

Molecular Weight

524.63

References & Citations

[1]Gowher H, et al. Mechanism of inhibition of DNA methyltransferases by cytidine analogs in cancer therapy. Cancer Biol Ther. 2004 Nov;3 (11) :1062-8.

Shipping Conditions

Room temperature

Scientific Category

Oligonucleotides

Clinical Information

No Development Reported

Frequently Asked Questions

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