PARL-IN-1
PARL-IN-1 is a potent PARL inhibitor with an IC50 value of 28 nM. PARL-IN-1 inhibits PARL and leads to a robust activation of the PINK1/Parkin pathway. PARL-IN-1 promotes PINK1/Parkin-dependent mitophagy[1].
Product Specifications
CAS Number
3034516-68-9
UNSPSC
12352005
Target
Mitophagy; PINK1/Parkin
Type
Reference compound
Related Pathways
Autophagy; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/parl-in-1.html
Solubility
10 mM in DMSO
Smiles
C[C@H](NC(C)=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(C(NCCCCC1=CC=CC=C1)=O)=O)C)=O)CC(C)C)=O)CC2=CC=CC=C2)=O)C(C)C)=O
Molecular Formula
C39H56N6O7
Molecular Weight
720.90
References & Citations
[1]Poláchová E, et, al. Chemical Blockage of the Mitochondrial Rhomboid Protease PARL by Novel Ketoamide Inhibitors Reveals Its Role in PINK1/Parkin-Dependent Mitophagy. J Med Chem. 2023 Jan 12;66 (1) :251-265.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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