CFTR activator 1
CFTR activator 1 is a potent and selective CFTR activator, with an EC50 of 23 nM. CFTR activator 1 can be used to ameliorate dry eye disease[1].
Product Specifications
CAS Number
[2768261-09-0]
UNSPSC
12352005
Target
CFTR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/cftr-activator-1.html
Purity
99.94
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N1C[C@@H](N(CC1)C(C2=CC=CC=C2)=O)C)C3=NN4C(C5=CC(OC)=C(C=C5)OC)=CC=NC4=C3
Molecular Formula
C27H27N5O4
Molecular Weight
485.53
References & Citations
[1]Kim BY, et, al. Synthetic Strategies for Improving Solubility: Optimization of Novel Pyrazolo[1,5- a]pyrimidine CFTR Activator That Ameliorates Dry Eye Disease. J Med Chem. 2023 Jan 12;66 (1) :413-434.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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