HPK1-IN-31
HPK1-IN-31 (compound 5i) is an orally active hematopoietic progenitor kinase 1 (HPK1) inhibitor with an IC50 value of 0.8 nM. HPK1-IN-31 has anti-tumour activity and has great potential for immunoresearch[1].
Product Specifications
CAS Number
3003026-16-9
UNSPSC
12352005
Target
MAP4K
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/hpk1-in-31.html
Solubility
10 mM in DMSO
Smiles
CC(O)(CN1C=C(C=N1)C2=CN=C3N=C2N[C@@H](C4=C(OCCCCC5=CC(N3)=CC=C5C#N)C=CC=C4)CO)C
Molecular Formula
C30H33N7O3
Molecular Weight
539.63
References & Citations
[1]Ming-Shu Wang, et al. Discovery of Macrocycle-Based HPK1 Inhibitors for T-Cell-Based Immunotherapy. J Med Chem. 2023 Jan 12;66 (1) :611-626.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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