ARS-2102

ARS-2102 is a potent covalent KRAS G12C inhibitor for use in cancer research[1].

Product Specifications

CAS Number

[2098509-21-6]

UNSPSC

12352005

Target

Ras

Type

Reference compound

Related Pathways

GPCR/G Protein; MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ars-2102.html

Solubility

10 mM in DMSO

Smiles

FC1=C(C2=C(C=CC=C2O)F)C(Cl)=CC3=C1N=C(N4CC(C4)N(C)C)N=C3N5[C@H](CN([C@@H](C5)C)C(C=C)=O)C

Molecular Formula

C28H31ClF2N6O2

Molecular Weight

557.03

References & Citations

[1]Xiaogen Yang, et al. Hindered Biaryl Bond Construction and Subsequent Diastereomeric Crystallization to Produce an Atropisomeric Covalent KRASG12C Inhibitor ARS-2102.Org. Process Res. Dev. 2022.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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