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SMYD3-IN-2

SMYD3-IN-2 is a SMYD3 inhibitor against gastric cancer via inducing lethal autophagy. SMYD3-IN-2 has inhibitory for SMYD3 and BGC823 cells with IC50 values of 0.81 μM and 0.75 μM, respectively. SMYD3-IN-2 can be used for the research of cancer[1].

Product Specifications

UNSPSC

12352005

Target

Autophagy; Histone Methyltransferase

Type

Reference compound

Related Pathways

Autophagy; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/smyd3-in-2.html

Solubility

10 mM in DMSO

Smiles

[H][C@]12CN(C([C@]1(O[C@@]3([C@@H]2C4=CC=C(C=C4)Br)C(NC5=CC=CC=C53)=O)O)=O)CC6=CC=CC=C6

Molecular Formula

C26H21BrN2O4

Molecular Weight

505.36

References & Citations

[1]Hong-Ping Zhu, et al. Discovery of tetrahydrofuranyl spirooxindole-based SMYD3 inhibitors against gastric cancer via inducing lethal autophagy. Eur J Med Chem. 2023 Jan 15;246:115009.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

SMYD3

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