SMYD3-IN-2
SMYD3-IN-2 is a SMYD3 inhibitor against gastric cancer via inducing lethal autophagy. SMYD3-IN-2 has inhibitory for SMYD3 and BGC823 cells with IC50 values of 0.81 μM and 0.75 μM, respectively. SMYD3-IN-2 can be used for the research of cancer[1].
Product Specifications
UNSPSC
12352005
Target
Autophagy; Histone Methyltransferase
Type
Reference compound
Related Pathways
Autophagy; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/smyd3-in-2.html
Solubility
10 mM in DMSO
Smiles
[H][C@]12CN(C([C@]1(O[C@@]3([C@@H]2C4=CC=C(C=C4)Br)C(NC5=CC=CC=C53)=O)O)=O)CC6=CC=CC=C6
Molecular Formula
C26H21BrN2O4
Molecular Weight
505.36
References & Citations
[1]Hong-Ping Zhu, et al. Discovery of tetrahydrofuranyl spirooxindole-based SMYD3 inhibitors against gastric cancer via inducing lethal autophagy. Eur J Med Chem. 2023 Jan 15;246:115009.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
SMYD3
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog