SIRT5 inhibitor 5
SIRT5 inhibitor 5 is a potent SIRT5 inhibitor with an IC50 value of 0.21 µM. SIRT5 inhibitor 5 does not occupy the NNAD+ -binding pocket and acts as a substrate-competitive inhibitor[1].
Product Specifications
CAS Number
2883730-60-5
UNSPSC
12352005
Target
Sirtuin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sirt5-inhibitor-5.html
Solubility
10 mM in DMSO
Smiles
CC1=NN(C(/C1=C/C2=CC=C(C=C2)C(O)=O)=O)C3=NC(C4=CC=C(C=C4)Cl)=CS3
Molecular Formula
C21H14ClN3O3S
Molecular Weight
423.87
References & Citations
[1]Yao J, et al. Pyrazolone derivatives as potent and selective small-molecule SIRT5 inhibitors. Eur J Med Chem. 2022 Dec 16;247:115024.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
SIRT5
Available Sizes
Frequently Asked Questions
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