BET-IN-13
Product Specifications
UNSPSC Description
BET-IN-13 is a potent BET inhibitor with an IC50 value of 1.6 nM. BET-IN-13 reduces LPS-induced TNF-α, IL-1β, IL-6, and NOS2 mRNA expression levels. BET-IN-13 shows anti-inflammatory activity. BET-IN-13 has the potential for the research of acute liver injury[1].
Target Antigen
Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Epigenetics
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/bet-in-13.html
Solubility
10 mM in DMSO
Smiles
CC1=C2C(NC=C3CN(C4=C(C(N32)=C1)C=C(C=C4)CS(C)(=O)=O)C(C5=CC=C6C=CC=CC6=C5)=O)=O
Molecular Weight
497.56
References & Citations
[1]Chen C, et al. Cyclization strategy leads to highly potent Bromodomain and extra-terminal (BET) Bromodomain inhibitors for the treatment of acute liver injury. Eur J Med Chem. 2022 Dec 16;247:115023.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-152213/BET-IN-13-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-152213/
Clinical Information
No Development Reported
CAS Number
2506823-08-9
Curated Selection
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