ASPER-29

ASPER-29 is Asperphenamate HY-129578 analog. ASPER-29 also is a dual cathepsin L and S inhibitor with IC50 value of 6.03 μM and 5.02 μM, respectively. ASPER-29 can be used for the research of the migration and invasion of cancer[1].

Product Specifications

CAS Number

[2630388-03-1]

UNSPSC

12352005

Target

Cathepsin

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/asper-29.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=CC=CC=C1)N[C@@H](C(OC[C@H](NS(=O)(C2=CC=C(C=C2)Br)=O)CC3=CC=CC=C3)=O)CC4=CC=CC=C4

Molecular Formula

C31H29BrN2O5S

Molecular Weight

621.54

References & Citations

[1]Haoqiang Huang, et al. Design and synthesis of dual cathepsin L and S inhibitors and antimetastatic activity evaluation in pancreatic cancer cells. Bioorg Med Chem Lett. 2022 Nov 23;80:129087.