JB062
Product Specifications
UNSPSC Description
JB062 is a nonmuscle myosin inhibitor with IC50 values of 1.6, 5.4, and >100 μM for Skeletal muscle myosin, Cardiac muscle myosin, and Smooth muscle myosin II, respectively. JB062 has cytotoxic to human cancer cells but not normal cells. JB062 can be used in research of muscle spasticity, chronic musculoskeletal pain, and hypertrophic cardiomyopathy[1].
Target Antigen
Myosin
Type
Reference compound
Related Pathways
Cytoskeleton
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/jb062.html
Solubility
10 mM in DMSO
Smiles
OC(C1=CC=CC=C1O2)=C(/C(C)=N/CC3=CC=C(OC)C=C3)C2=O
Molecular Weight
323.34
References & Citations
[1]Smith JD, et, al. Isoform selectivities of novel 4-hydroxycoumarin imines as inhibitors of myosin II. Eur J Med Chem. 2022 Dec 12;247:115008.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-152206/JB062-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-152206/
Clinical Information
No Development Reported
CAS Number
2417988-00-0
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
NBP3-25424 100 µL
Rabbit Monoclonal Diphtheria Toxin Antibody (HL1808) - CRM197 Mutant - Azide and BSA Free
Ask
View Details 