AMPD2 inhibitor 2
AMPD2 inhibitor 2 (compound 21) is a potent AMP deaminase 2 (AMPD2) inhibitor with IC50s of 0.1 μM and 0.28μM for hAMPD2 and mAMPD2, respectively. AMPD2 inhibitor 2 has the potential for evaluating the physiological role of AMPD2 in mice maintained on a high fat diet[1].
Product Specifications
CAS Number
[3026893-31-9]
UNSPSC
12352005
Target
Adenosine Deaminase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/ampd2-inhibitor-2.html
Solubility
10 mM in DMSO
Smiles
CC1(CN(C2=CC=C(C(F)=C2N1CC3=CC=C(C=C3)COC4=CC=C(C=C4)CO)F)C(N)=O)C
Molecular Formula
C26H27F2N3O3
Molecular Weight
467.51
References & Citations
[1]Yuki Kitao, et al. The discovery of 3,3-dimethyl-1,2,3,4-tetrahydroquinoxaline-1-carboxamides as AMPD2 inhibitors with a novel mechanism of action. Bioorg Med Chem Lett. 2022 Dec 20;80:129110.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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