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Tankyrase-IN-4

Tankyrase-IN-4 is a tankyrase 1 (TNKS1) inhibitor with an IC50 value of 0.8 nM. Tankyrase-IN-4 can be used for the research of cancer[1].

Product Specifications

UNSPSC

12352005

Target

PARP

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tankyrase-in-4.html

Solubility

10 mM in DMSO

Smiles

CNC([C@@H](NC(C1=CN=C2C=CC=CC2=C1)=O)CNC(CCN3C(NC(C4=C3C=CC=C4)=O)=O)=O)=O

Molecular Formula

C25H24N6O5

Molecular Weight

488.50

References & Citations

[1]Alba L Montoya, et al. Combining pharmacophore models derived from DNA-encoded chemical libraries with structure-based exploration to predict Tankyrase 1 inhibitors. Eur J Med Chem. 2023 Jan 15;246:114980.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

TNKS1/PARP5A

Frequently Asked Questions

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