ChoKα inhibitor-4

ChoKα inhibitor-4 is a bioisosteric inhibitor of HChoK α1 (IC50=0.66 μM), with inhibitory and antiproliferative effect on cancer cells. ChoKα inhibitor-4 induces apoptosis via mitochondrial pathway, and reduces anti-apoptotic proteins expression[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/chokα-inhibitor-4.html

Solubility

10 mM in DMSO

Smiles

C=CCCCCN(C1=CC=[N+](C2=C1C=CS2)CC3=CC=C(C=C3)SCCSC4=CC=C(C=C4)C[N+]5=CC=C(C6=C5SC=C6)N(CCCCC=C)CCCCC=C)CCCCC=C.[Br-].[Br-]

Molecular Formula

C54H68Br2N4S4

Molecular Weight

1061.21

References & Citations

[1]Luque-Navarro PM, et al. New bioisosteric sulphur-containing choline kinase inhibitors with a tracked mode of action. Eur J Med Chem. 2023 Jan 15;246:115003.