ChoKα inhibitor-4
Product Specifications
UNSPSC Description
ChoKα inhibitor-4 is a bioisosteric inhibitor of HChoK α1 (IC50=0.66 μM), with inhibitory and antiproliferative effect on cancer cells. ChoKα inhibitor-4 induces apoptosis via mitochondrial pathway, and reduces anti-apoptotic proteins expression[1].
Target Antigen
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/chokα-inhibitor-4.html
Solubility
10 mM in DMSO
Smiles
C=CCCCCN(C1=CC=[N+](C2=C1C=CS2)CC3=CC=C(C=C3)SCCSC4=CC=C(C=C4)C[N+]5=CC=C(C6=C5SC=C6)N(CCCCC=C)CCCCC=C)CCCCC=C.[Br-].[Br-]
Molecular Weight
1061.21
References & Citations
[1]Luque-Navarro PM, et al. New bioisosteric sulphur-containing choline kinase inhibitors with a tracked mode of action. Eur J Med Chem. 2023 Jan 15;246:115003.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-152193/ChoKα-inhibitor-4-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-152193/
Clinical Information
No Development Reported
Curated Selection
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