ChoKα inhibitor-4
ChoKα inhibitor-4 is a bioisosteric inhibitor of HChoK α1 (IC50=0.66 μM), with inhibitory and antiproliferative effect on cancer cells. ChoKα inhibitor-4 induces apoptosis via mitochondrial pathway, and reduces anti-apoptotic proteins expression[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/chokα-inhibitor-4.html
Solubility
10 mM in DMSO
Smiles
C=CCCCCN(C1=CC=[N+](C2=C1C=CS2)CC3=CC=C(C=C3)SCCSC4=CC=C(C=C4)C[N+]5=CC=C(C6=C5SC=C6)N(CCCCC=C)CCCCC=C)CCCCC=C.[Br-].[Br-]
Molecular Formula
C54H68Br2N4S4
Molecular Weight
1061.21
References & Citations
[1]Luque-Navarro PM, et al. New bioisosteric sulphur-containing choline kinase inhibitors with a tracked mode of action. Eur J Med Chem. 2023 Jan 15;246:115003.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS7172990 Inquire
Rabbit anti-Escherichia fergusonii (strain 35469/DSM 13698/CDC 0568-73) METK Polyclonal Antibody
Ask
View Details 031653-Biotin 200 µL
ADPRH, CT (ADPRH, ARH1, [Protein ADP-ribosylarginine] hydrolase, ADP-ribose-L-arginine cleaving enzyme) (Biotin) discontinued
Ask
View Details 302773-Biotin 100 µL
SRGAP2 (SLIT-ROBO Rho GTPase-activating Protein 2, srGAP2, Formin-Binding Protein 2, Rho GTPase-activating Protein 34, SRGAP2, ARHGAP34, FNBP2, KIAA0456, SRGAP2A) (Biotin) discontinued
Ask
View Details