Topoisomerase IIα-IN-5
Topoisomerase IIα-IN-5 is a topoisomerase II (topo II) α catalytic inhibitor. Topoisomerase IIα-IN-5 intercalates into DNA and binds to the DNA minor groove. Topoisomerase IIα-IN-5 exhibits better efficacy and less genotoxicity than Etoposide.
Product Specifications
CAS Number
3037545-23-3
UNSPSC
12352005
Target
Apoptosis; Topoisomerase
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/topoisomerase-iiα-in-5.html
Solubility
10 mM in DMSO
Smiles
O=C1C=C(OC2=CC(OCC(CNCCN3CCCCC3)O)=CC(O)=C12)C4=CC=CC=C4
Molecular Formula
C25H30N2O5
Molecular Weight
438.52
References & Citations
[1]Jeon KH, et al. Synthesis and evaluation of 7- (3-aminopropyloxy) -substituted flavone analogue as a topoisomerase IIα catalytic inhibitor and its sensitizing effect to enzalutamide in castration-resistant prostate cancer cells. Eur J Med Chem. 2023 Jan 15;246:114999.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Topo II
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