SEW84

SEW84 is an inhibitor of Aha1-stimulated Hsp90 (ASH) ATPase activity. SEW84 inhibits Aha1-stimulated Hsp90 (ASH) activity with an IC50 value of 0.3 μM. SEW84 can be used in the study of protein deposition diseases[1].

Product Specifications

CAS Number

[259089-67-3]

Product Name Alternative

SEW04784

UNSPSC

12352005

Target

HSP

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/sew84.html

Purity

99.73

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=CN1C2=CC=C(C=C2)F)NNC(NC3=CC=CC(C(F)(F)F)=C3)=S

Molecular Formula

C19H14F4N4OS

Molecular Weight

422.40

References & Citations

[1]Jay K Singh, et al. Management of Hsp90-Dependent Protein Folding by Small Molecules Targeting the Aha1 Co-Chaperone. Cell Chem Biol. 2020 Mar 19;27 (3) :292-305.e6.