CYP4Z1-IN-1

CYP4Z1-IN-1 (compound 7c) is a potent CYP4Z1 inhibitor, with an IC50 of 41.8 nM. CYP4Z1-IN-1 decreases the expression of breast CSCs stemness markers, spheroid formation, and metastatic ability as well as tumor-initiation capability in a concentration-dependent manner in vitro and in vivo[1].

Product Specifications

CAS Number

[2760611-38-7]

UNSPSC

12352005

Target

Cytochrome P450

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cyp4z1-in-1.html

Solubility

10 mM in DMSO

Smiles

O=C(CCCC1=CC=C(C=C1)N/C=N/O)OCC

Molecular Formula

C13H18N2O3

Molecular Weight

250.29

References & Citations

[1]Yuan Y, et al. Identification of a Novel Potent CYP4Z1 Inhibitor Attenuating the Stemness of Breast Cancer Cells through Lead Optimization. J Med Chem. 2022 Dec 8;65 (23) :15749-15769.