JZP-MA-13
JZP-MA-13 is a selective α/β-hydrolase domain 6 (ABHD6) inhibitor with an IC50 of 392 nM. JZP-MA-13 shows no inhibition of MAGL, ABHD12, FAAH, or other serine hydrolases. JZP-MA-13 is a positron emission tomography (PET) ligand for in vivo imaging of the ABHD6[1].
Product Specifications
CAS Number
3034900-00-7
UNSPSC
12352005
Target
MAGL
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/jzp-ma-13.html
Solubility
10 mM in DMSO
Smiles
FC1=CC=C(C=C1)N(C)C(OC2=NSN=C2N3CCOCC3)=O
Molecular Formula
C14H15FN4O3S
Molecular Weight
338.36
References & Citations
[1]Karine Mardon, et al. Utilizing PET and MALDI Imaging for Discovery of a Targeted Probe for Brain Endocannabinoid α/ β-Hydrolase Domain 6 (ABHD6) . J Med Chem. 2022 Dec 14.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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