PROTAC SOS1 degrader-3
Product Specifications
UNSPSC Description
PROTAC SOS1 degrader-3 is a potent PROTAC SOS1 degrader. PROTAC SOS1 degrader-3 effectively targeted SOS1 for degradation through the ubiquitin-proteasome system[1].
Target Antigen
PROTACs; Ras
Type
Reference compound
Related Pathways
GPCR/G Protein;MAPK/ERK Pathway;PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-sos1-degrader-3.html
Solubility
10 mM in DMSO
Smiles
NC1=CC(C(F)(F)F)=CC([C@H](NC2=C3C=C(OC)C(OCC(NC4=CC=CC(C5=O)=C4CN5C(C(N6)=O)CCC6=O)=O)=CC3=NC(C)=N2)C)=C1
Molecular Weight
691.66
References & Citations
[1]Yujia Bian, et al. Development of SOS1 Inhibitor-Based Degraders to Target KRAS-Mutant Colorectal Cancer. J Med Chem. 2022 Dec 22;65(24):16432-16450.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-152145/PROTAC-SOS1-degrader-3-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-152145/
Clinical Information
No Development Reported
CAS Number
3029320-99-5
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