PROTAC SOS1 degrader-3

PROTAC SOS1 degrader-3 is a potent PROTAC SOS1 degrader. PROTAC SOS1 degrader-3 effectively targeted SOS1 for degradation through the ubiquitin-proteasome system[1].

Product Specifications

CAS Number

[3029320-99-5]

UNSPSC

12352005

Target

PROTACs; Ras; SOS1

Type

Reference compound

Related Pathways

GPCR/G Protein; MAPK/ERK Pathway; PROTAC

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/protac-sos1-degrader-3.html

Solubility

10 mM in DMSO

Smiles

NC1=CC(C(F)(F)F)=CC([C@H](NC2=C3C=C(OC)C(OCC(NC4=CC=CC(C5=O)=C4CN5C(C(N6)=O)CCC6=O)=O)=CC3=NC(C)=N2)C)=C1

Molecular Formula

C34H32F3N7O6

Molecular Weight

691.66

References & Citations

[1]Yujia Bian, et al. Development of SOS1 Inhibitor-Based Degraders to Target KRAS-Mutant Colorectal Cancer. J Med Chem. 2022 Dec 22;65 (24) :16432-16450.