KY216
KY216 (Tubulin polymerization-IN-41) is a potent tubulin polymerization inhibitor with the IC50 of 2.61 μM. KY216 targets the Colchicine-binding site of tubulin. KY216 can be used for the study of non-small cell lung cancer (NSCLC) and breast cancer[1][2].
Product Specifications
CAS Number
2804026-81-9
Product Name Alternative
Tubulin polymerization-IN-41
UNSPSC
12352005
Target
Apoptosis; Microtubule/Tubulin
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tubulin-polymerization-in-41.html
Solubility
10 mM in DMSO
Smiles
O=C(N1[C@@H](C2=CC3=C(C=C2C[C@H]14)OCCO3)C5=CC(Cl)=C(C(Cl)=C5)OC)NC4=O
Molecular Formula
C20H16Cl2N2O5
Molecular Weight
435.26
References & Citations
[1]Jiafu Leng, et al. Discovery of Novel N-Heterocyclic-Fused Deoxypodophyllotoxin Analogues as Tubulin Polymerization Inhibitors Targeting the Colchicine-Binding Site for Cancer Treatment. J Med Chem. 2022 Dec 22;65 (24) :16774-16800. |[2]He XY, et al. KY216-tubulin complex captures VASH2 to inhibit NSCLC metastasis. Nat Commun. 2025 Dec 4.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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