PROTAC HDAC6 degrader 1
PROTAC HDAC6 degrader (Compound A6) is a potent and selective PROTAC HDAC6 degrader with a DC50 of 3.5 nM. PROTAC HDAC6 degrader shows promising antiproliferative activity via inducing apoptosis in myeloid leukemia cell lines[1].
Product Specifications
CAS Number
2785404-76-2
UNSPSC
12352005
Target
Apoptosis; HDAC; PROTACs
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-hdac6-degrader-1.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=C(C=C1)NC(CCCCCCCNC(COC2=CC=CC(C(N3C4CCC(NC4=O)=O)=O)=C2C3=O)=O)=O)NCCCCCCC(NO)=O
Molecular Formula
C37H46N6O10
Molecular Weight
734.80
References & Citations
[1]Sinatra L, et al. Solid-Phase Synthesis of Cereblon-Recruiting Selective Histone Deacetylase 6 Degraders (HDAC6 PROTACs) with Antileukemic Activity. J Med Chem. 2022 Dec 22;65 (24) :16860-16878.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC1; HDAC6
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