AChE/BChE/MAO-B-IN-4
Product Specifications
UNSPSC Description
AChE/BChE/MAO-B-IN-4, an indan-1-one derivative, is a potent MAO-B inhibitor with an IC50 of 0.0393 μM for human MAO-B. AChE/BChE/MAO-B-IN-4 is a potent AChE and BChE enzyme inhibitor, with IC50s of 0.0458 μM and 0.075 μM for human AChE and BChE enzyme, respectively. AChE/BChE/MAO-B-IN-4 shows significant antioxidant activity and prevent β-amyloid plaque aggregation. AChE/BChE/MAO-B-IN-4 has the potential for Alzheimer's disease (AD) research[1].
Target Antigen
Cholinesterase (ChE); Monoamine Oxidase
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ache-bche-mao-b-in-4.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CC=C(/C=C(CC2=C3C=C(OC)C(OC)=C2)\C3=O)C=C1)CN(C)CCCN(C)C
Molecular Weight
451.56
References & Citations
[1]Begüm Nurpelin Sağlık, et al. Design, Synthesis, and In Vitro and In Silico Approaches of Novel Indanone Derivatives as Multifunctional Anti-Alzheimer Agents. ACS Omega. 2022 Dec 7;7(50):47378-47404.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-152114/AChE-BChE-MAO-B-IN-4-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-152114/
Clinical Information
No Development Reported
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