AChE/MAO-IN-1

AChE/MAO-IN-1 (Compound D28) is a potent AChE, MAO-A and MAO-B inhibitor with IC50s of 0.0248, 0.0409 and 0.1108 μM against human AChE, MAO-B and MAO-A, respectively[1].

Product Specifications

UNSPSC

12352005

Target

Amyloid-β; Cholinesterase (ChE) ; Monoamine Oxidase

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ache-mao-in-1.html

Solubility

10 mM in DMSO

Smiles

O=C(NC1=CC=C(/C=C(CC2=C3C=CC(OC)=C2)\C3=O)C=C1)CN(C)CCC

Molecular Formula

C23H26N2O3

Molecular Weight

378.46

References & Citations

[1]Sağlık BN, et al. Design, Synthesis, and In Vitro and In Silico Approaches of Novel Indanone Derivatives as Multifunctional Anti-Alzheimer Agents. ACS Omega. 2022 Dec 7;7 (50) :47378-47404.