(R, R) -LRRK2-IN-7

(R, R) -LRRK2-IN-7 is the isomer of LRRK2-IN-7 (HY-152107) . LRRK2-IN-7 is a potent, selective, and CNS-penetrant LRRK2 kinase inhibitor with an IC50 of 0.9 nM. LRRK2-IN-7 shows >1000-fold selectivity over other kinases, ion channels, and CYP enzymes.

Product Specifications

CAS Number

[2307277-92-3]

UNSPSC

12352005

Target

LRRK2

Type

Reference compound

Related Pathways

Autophagy

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/r-r-lrrk2-in-7.html

Solubility

10 mM in DMSO

Smiles

CC(C)(O)[C@@H]1CCN(C1)C2=NC=NC(N3C4=CC([C@]5(CC56CC6)C#N)=CC=C4C=N3)=C2

Molecular Formula

C24H26N6O

Molecular Weight

414.50

References & Citations

[1]David A Candito, et al. Discovery and Optimization of Potent, Selective, and Brain-Penetrant 1-Heteroaryl-1 H-Indazole LRRK2 Kinase Inhibitors for the Treatment of Parkinson's Disease. J Med Chem. 2022 Dec 22;65 (24) :16801-16817.