Metallo-β-lactamase-IN-9

Metallo-β-lactamase-IN-9 (Compound 23) is a pan metallo-beta-lactamase (MBL) inhibitor with IC50s of 35, 269 and 369 nM against NDM-1, VIM-1 and IMP-1, respectively[1].

Product Specifications

CAS Number

[1802363-75-2]

UNSPSC

12352005

Target

Bacterial; Beta-lactamase

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/metallo-β-lactamase-in-9.html

Solubility

10 mM in DMSO

Smiles

OCC1=CC=C(C=C1)C2=CC=NC(S(=O)(N)=O)=C2C3=NN=NN3

Molecular Formula

C13H12N6O3S

Molecular Weight

332.34

References & Citations

[1]Mandal M, et al. Rapid Evolution of a Fragment-like Molecule to Pan-Metallo-Beta-Lactamase Inhibitors: Initial Leads toward Clinical Candidates. J Med Chem. 2022 Dec 22;65 (24) :16234-16251.