FGFR-IN-9
FGFR-IN-9 (Compound 19) is a potent, reversible and orally active FGFR inhibitor with an IC50 of 17.1, 29.6, 30.7, 46.7 and 64.3 nM against FGFR4WT, FGFR3, FGFR4V550L, FGFR2 and FGFR1, respectively[1].
Product Specifications
CAS Number
3024090-08-9
UNSPSC
12352005
Target
FGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/fgfr-in-9.html
Solubility
10 mM in DMSO
Smiles
O=S(N1C=CC2=CN=C(NC3=CC=C(N4C[C@H](C)N[C@H](C)C4)C=C3)N=C21)(C5=CC=CC(OC)=C5)=O
Molecular Formula
C25H28N6O3S
Molecular Weight
492.59
References & Citations
[1]Xie W, et al. Discovery of 2-Amino-7-sulfonyl-7 H-pyrrolo [2, 3-d] pyrimidine Derivatives as Potent Reversible FGFR Inhibitors with Gatekeeper Mutation Tolerance: Design, Synthesis, and Biological Evaluation. Journal of Medicinal Chemistry, 2022.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNCB1576-500 1x 500 µL
Cytokeratin, Basic (Type II or HMW) (Epithelial Marker) (KRTH/1576R), Biotin conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
AP08276PU-N 50 µg
Eph receptor A2 (EPHA2) (450-500) Rabbit Polyclonal Antibody
Sign In for Pricing
View Details ![HLA Class II DR Monoclonal Antibody [Clone ID: L243]](https://cdn.genprice.uk/products/937/68dd189c061270361e8fcd8e/imageurl/am26708le-n.webp)
AM26708LE-N 100 µg
HLA Class II DR Monoclonal Antibody [Clone ID: L243]
Sign In for Pricing
View Details 
E-UNEL-H0092-01 5x 96 Tests
Uncoated Human IL-2 (Interleukin 2) ELISA Kit
Sign In for Pricing
View Details