CYP1B1-IN-3
CYP1B1-IN-3 is a potent and selective CYP1B1 inhibitor with IC50 values of 6.6, 347.3, >10000 nM for CYP1B1, CYP1A1, CYP1A2, respectively. CYP1B1-IN-3 inhibits cell migration and invasion. CYP1B1-IN-3 inhibits P-gp, AKT/ERK, FAK/SRC, and EMT pathways[1].
Product Specifications
CAS Number
[2872575-51-2]
UNSPSC
12352005
Target
Cytochrome P450
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cyp1b1-in-3.html
Solubility
10 mM in DMSO
Smiles
COC1=CC(NC2=NC(C3=NC(C4=C(C=CC=C4)F)=CS3)=CS2)=CC(OC)=C1
Molecular Formula
C20H16FN3O2S2
Molecular Weight
413.49
References & Citations
[1]Mao J, et al. Structure-Based Drug Design and Synthesis of Novel N-Aryl-2,4-bithiazole-2-amine CYP1B1-Selective Inhibitors in Overcoming Taxol Resistance in A549 Cells. J Med Chem. 2022 Dec 22;65 (24) :16451-16480.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CYP1
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