AXL-IN-14
AXL-IN-14 is a potent and orally active AXL inhibitor with an IC50 value of 0.8 nM. AXL-IN-14 inhibits Gas6/AXL-mediated cell migration and invasion. AXL-IN-14 decreases the expression of p-AXL and p-AKT proteins. AXL-IN-14 shows anti-tumor activity[1].
Product Specifications
CAS Number
2947506-65-0
UNSPSC
12352005
Target
TAM Receptor
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/axl-in-14.html
Solubility
10 mM in DMSO
Smiles
FC1=CC(NC(C2=CN(C=C(C2=O)C3=CC=C(C=C3)F)C(C)C)=O)=CC=C1OC4=CC=NC5=C4OC6=CC=CC=C6N5
Molecular Formula
C32H24F2N4O4
Molecular Weight
566.55
References & Citations
[1]Zhengsheng Zhan, et al. Discovery of 10H-Benzo[b]pyrido[2,3-e][1,4]oxazine AXL Inhibitors via Structure-Based Drug Design Targeting c-Met Kinase. J. Med. Chem. 2022.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Axl
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