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AXL-IN-14

AXL-IN-14 is a potent and orally active AXL inhibitor with an IC50 value of 0.8 nM. AXL-IN-14 inhibits Gas6/AXL-mediated cell migration and invasion. AXL-IN-14 decreases the expression of p-AXL and p-AKT proteins. AXL-IN-14 shows anti-tumor activity[1].

Product Specifications

CAS Number

2947506-65-0

UNSPSC

12352005

Target

TAM Receptor

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/axl-in-14.html

Solubility

10 mM in DMSO

Smiles

FC1=CC(NC(C2=CN(C=C(C2=O)C3=CC=C(C=C3)F)C(C)C)=O)=CC=C1OC4=CC=NC5=C4OC6=CC=CC=C6N5

Molecular Formula

C32H24F2N4O4

Molecular Weight

566.55

References & Citations

[1]Zhengsheng Zhan, et al. Discovery of 10H-Benzo[b]pyrido[2,3-e][1,4]oxazine AXL Inhibitors via Structure-Based Drug Design Targeting c-Met Kinase. J. Med. Chem. 2022.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Axl

Frequently Asked Questions

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