SIAIS100
SIAIS100 is a potent BCR-ABL PROTAC degrader with an DC50 value of 2.7 nM. SIAIS100 can be used to research chronic myeloid leukemia (CML) [1].
Product Specifications
CAS Number
3033463-06-5
UNSPSC
12352005
Target
Bcr-Abl; PROTACs
Type
Reference compound
Related Pathways
PROTAC; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/siais100.html
Solubility
10 mM in DMSO
Smiles
O=C1CCC(C(N1)=O)N2CC3=C(C2=O)C=CC=C3SCCCCCCN4CCN(CC4)C5CCN(CC5)C6=NC=C(C=C6C7=CC=NN7)C(NC8=CC=C(C=C8)OC(F)(Cl)F)=O
Molecular Formula
C44H50ClF2N9O5S
Molecular Weight
890.44
References & Citations
[1]Liu H, et al. Discovery and characterization of novel potent BCR-ABL degraders by conjugating allosteric inhibitor. Eur J Med Chem. 2022 Dec 15;244:114810.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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