URAT1 inhibitor 4
URAT1 inhibitor 4, a Lesinurad derivative, is a potent and orally active URAT1 inhibitor with an IC50 of 7.56 μM. URAT1 inhibitor 4 has higher in vivo urate-lowering efficacy than Lesinurad (HY-15258) [1].
Product Specifications
CAS Number
[2700292-02-8]
UNSPSC
12352005
Target
GLUT; URAT1
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/urat1-inhibitor-4.html
Solubility
10 mM in DMSO
Smiles
O=C(NS(=O)(C1=CC=C(C=C1)Br)=O)CSC2=NC3=C(C(N2C4=CC=C(C5=C4C=CC=C5)C6CC6)=O)C=CS3
Molecular Formula
C27H20BrN3O4S3
Molecular Weight
626.56
References & Citations
[1]Zhang J, et al. Design, synthesis and activity evaluation of novel lesinurad analogues containing thienopyrimidinone or pyridine substructure as human urate transporter 1 inhibitors. Eur J Med Chem. 2022 Dec 15;244:114816.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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