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Tubulin/MMP-IN-2

Tubulin/MMP-IN-2 is dual inhibitor of tubulin and matrix metalloproteinases. Tubulin/MMP-IN-2 can strongly inhibit tubulin polymerization and induces cell apoptosis. Tubulin/MMP-IN-2 has inhibitory activities against MMP-2, MMP-3 and MMP-9 with IC50 values of 24.95 μM, 31.60 μM and 22.37 μM, respectively. Tubulin/MMP-IN-2 can be used for the research of cancer[1].

Product Specifications

CAS Number

2734877-51-9

UNSPSC

12352005

Target

Apoptosis; Microtubule/Tubulin; MMP

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; Metabolic Enzyme/Protease

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tubulin-mmp-in-2.html

Solubility

10 mM in DMSO

Smiles

CCOP(OCC)(C(C1=CC=C(C=C1)OC)NC2=CC=C(C=C2)CC(OCCOC3=CC(/C=C\C4=CC(OC)=C(C(OC)=C4)OC)=CC=C3OC)=O)=O

Molecular Formula

C40H48NO11P

Molecular Weight

749.78

References & Citations

[1]Xiaochao Huang, et al. Novel combretastatin A-4 derivative containing aminophosphonates as dual inhibitors of tubulin and matrix metalloproteinases for lung cancer treatment. Eur J Med Chem. 2022 Dec 15;244:114817.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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