KRAS G12C inhibitor 65
KRAS G12C inhibitor 65 is a potent and covalent KRASG12C inhibitor that traps KRASG12C in the GDP-bound state. KRASG12C IN-1 exhibits potent antitumor activity against KRAS-mutant non-small cell lung cancer[1].
Product Specifications
UNSPSC
12352005
Target
Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/kras-g12c-inhibitor-65.html
Solubility
10 mM in DMSO
Smiles
O=C(N1CCN(CC1)C(NC2=CC(C3=C(C=CC=C3)F)=C(C=C2)Cl)=O)CCl
Molecular Formula
C19H18Cl2FN3O2
Molecular Weight
410.27
References & Citations
[1]Cheng R, et, al. Design, synthesis, and evaluation of 4 (1H) -quinolinone and urea derivatives as KRASG12C inhibitors with potent antitumor activity against KRAS-mutant non-small cell lung cancer. Eur J Med Chem. 2022 Dec 15;244:114808.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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