RET-IN-20
RET-IN-20 is a potent RET inhibitor with an IC50 value of 13.7 nM. RET-IN-20 decreases the expression of p-Ret, p-Shc protein. RET-IN-20 induces apoptosis. RET-IN-20 shows antiproliferative and anti-tumor activity[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; RET
Type
Reference compound
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ret-in-20.html
Solubility
10 mM in DMSO
Smiles
COC1=C(C=C2C(N=CC=C2OC3=CC=C(C=C3F)NC4=NN(C=C4C(NC56CC7CC(C6)CC(C5)C7)=O)C)=C1)C(N)=O
Molecular Formula
C32H33FN6O4
Molecular Weight
584.64
References & Citations
[1]Zhang Y, et al. 1-Methyl-3- ((4- (quinolin-4-yloxy) phenyl) amino) -1H-pyrazole-4-carboxamide derivatives as new rearranged during Transfection (RET) kinase inhibitors capable of suppressing resistant mutants in solvent-front regions. Eur J Med Chem. 2022 Dec 15;244:114862.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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